OPTIMA

Optimal treatment for patients with solid tumours in Europe through Artificial intelligence

The number of incident cancer cases in Europe is projected to increase by 14% by 2030. This leads to a growing demand for innovative cancer treatments among patients. In this context, the EU- and EFPIA-funded (IMI2 Joint Undertaking) OPTIMA project will bring together the European Respiratory Society and the European Lung Foundation, alongside 36 other partners. The aim is to design, develop and deliver the first interoperable European real-world oncology data and evidence generation platform, along with decision support toolsets for prostate, lung and breast cancer. OPTIMA will establish best practice procedures for the integration of analytics and evidence informed by AI tools and technology.

OPTIMA is a multi-stakeholder-led consortium with the vision that each and every patient should have access to the most up-to-date individualised treatments and to innovative therapies. In that perspective, we will design, develop and deliver the first interoperable and GDPR-compliant European real-world oncology data and evidence generation platform, along with decision support toolsets for prostate, lung and breast cancer. By designing this platform from the onset based on the needs of the clinicians and patients in an inclusive and sustainable way, OPTIMA aims to strengthen shared decision-making based on innovative data and AI-driven technology and tools.
To achieve our vision, we have united the key partners from other data-driven European-wide oncology initiatives (PIONEER, EHDEN, HARMONY) in our project along with Europe’s leading clinicians in the fields of breast, prostate and lung cancer that all have leading roles in medical societies such as ERS, ESMO and EAU. At the core of the OPTIMA project are the major guideline offices of the three indications, whilst the project is further strengthened by patient advocacy groups, well-known academic partners and 6 SMEs covering the needed expertise to implement OPTIMA successfully.
The platform will build on existing open-source solutions such as the OMOP-CDM, tranSMART and OHDSI ATLAS whilst developing novel AI models based on federated learning to facilitate knowledge discovery. At the start of the project, we will already have access to datasets covering over 200 million people in Europe, along with data from high-quality patient cohorts for AI model building. Moreover, the platform will be hosted in kind on existing infrastructure provided by Helmholtz Institute in Germany. Finally, OPTIMA envisions sustainability of its platform through a value-based approach with various business models for commercial users.

OPTIMA

Funding

Horizont 2020

Area

Health

Duration

1 Oct 2021 - 30 Sep 2026

Budget

€ 22 689 967,00

Our role

Dissemination & Communication, Stakeholder Dialogue

Partners

38

Countries

14

Coordinator

STICHTING EUROPEAN UROLOGICAL FOUNDATION, Netherlands

Participants

  • LUNDS UNIVERSITET, Sweden
  • ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM, Netherlands
  • ASSOCIATION EISBM, France
  • THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN, United Kingdom
  • TARTU ULIKOOL, Estonia
  • UNIVERSITA VITA-SALUTE SAN RAFFAELE, Italy
  • QUEEN MARY UNIVERSITY OF LONDON, United Kingdom
  • HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV, Germany
  • HELIOS KLINIKUM EMIL VON BEHRING GMBH, Germany
  • UPPSALA UNIVERSITET, Sweden
  • THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD, United Kingdom
  • UNIVERSITAT WIEN, Austria
  • ISTITUTO EUROPEO DI ONCOLOGIA SRL, Italy
  • LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN, Germany
  • UNIVERSITY COLLEGE LONDON, United Kingdom
  • EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL, Belgium
  • INSTITUT DE CANCEROLOGIE DE L’OUEST, France
  • UNIVERSITEIT MAASTRICHT, Netherlands
  • FUNDACIO INSTITUT UNIVERSITARI PERA LA RECERCA A L’ATENCIO PRIMARIA DE SALUT JORDI GOL I GURINA, Spain
  • EUROPEAN RESPIRATORY SOCIETY, Switzerland
  • DEUTSCHE KREBSGESELLSCHAFT EV, Germany
  • EUROPEAN LUNG FOUNDATION, United Kingdom
  • TTOPSTART BV, Netherlands
  • GMV SOLUCIONES GLOBALES INTERNET SAU, Spain
  • INFORMATION TECHNOLOGY FOR TRANSLATIONAL MEDICINE (ITTM) SA, Luxembourg
  • SMART REPORTING GMBH, Germany
  • OWKIN FRANCE, France
  • ARTTIC INNOVATION GMBH, Germany
  • YDEAL.NET SOFTWARE LDA, Portugal
  • PFIZER LIMITED, United Kingdom
  • BAYER AKTIENGESELLSCHAFT, Germany
  • AMGEN, Belgium
  • F. HOFFMANN-LA ROCHE AG, Switzerland
  • ABBVIE INC, United States
  • ASTRAZENECA AB, Sweden
  • MUTABOR TECHNOLOGIES GMBH, Germany
  • REGION UPPSALA, Sweden